Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/288392551?client_source=feed&format=rss
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Sunday, March 3, 2013
Sequester Real Talk: The 3 Dumbest Things About This Truly Dumb Law (Atlantic Politics Channel)
Saturday, March 2, 2013
Apple award cut to $599 million in Samsung patent case
March 1 (Reuters) - Celtic are surprised that arch-rivals Rangers were deemed to have gained no competitive advantage for making undisclosed payments to players and staff from 2000-11, the Scottish Premier League leaders said on Friday. Former champions Rangers were fined 250,000 pounds ($375,300) by the Scottish Premier League (SPL) on Thursday although the Glasgow club were told they could keep the titles they won during the 11-year period the payments were made. ...
Source: http://news.yahoo.com/apple-award-cut-599-million-samsung-patent-case-203557783.html
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Improved, more terrifying BigDog robot flings cinder blocks
Everyone's favorite buzzing, prancing robot, the BigDog from Boston Dynamics, has a new trick. It now has an arm which can be used to manipulate nearby objects with great force ? for instance, in this video, tossing a cinder block a good 15 feet.
The approach Boston Dynamics is taking is to use the robot's whole body as power for its actions. So, as you can see, it actually bends down to pick up the block rather than just extending its arm further. And it tilts its whole body to one side as a counterweight to the block before it throws.
BigDog's creators point out (in their characteristically minimal YouTube description) that this is how athletes and real animals perform many tasks, and it does appear to be practical ? but it's also eerily lifelike. The improved body and lessened noise from the original have failed to make its uncanny animal-like movements any less unnerving.
The latest news from the DARPA-funded BigDog project can always be found on the Boston Dynamics YouTube page. They typically upload a video or two every few months.
Devin Coldewey is a contributing writer for NBC News Digital. His personal website is coldewey.cc.
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ASTORINO ANNOUNCES WESTCHESTER COUNTY AS HOME OF ...
1 Mar, 2013
Posted by StacyASTORINO ANNOUNCES WESTCHESTER COUNTY AS HOME OF
43rd ANNUAL AMERICAN GOLD CUP EQUESTRIAN COMPETITION
10,000 visitors expected to directly add at least $6 million to local economy
Signature event for ?Meet Me in Westchester? tourism campaign
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Featured left to right, Michael Morrissey, President, Stadium Jumping; Frank Madden, Old Salem Farm head trainer/American Gold Cup organizer; Robert P. Astorino, Westchester County Executive; McLain Ward, two-time Olympic Gold Medalist from Brewster, N.Y.; Valerie Angeli, ASPCA senior director, equine and special projects.
Westchester County Executive Robert P. Astorino in partnership with the American Gold Cup today announced that one of the most iconic equestrian events in the world of International Show Jumping will be held at Old Salem Farm in North Salem Sept. 11-15, 2013. The event is expected to attract 10,000 people to Westchester County, directly adding at least $6 million to the local economy.
The ASPCA (The American Society for the Prevention of Cruelty to Animals) and JustWorld International have been selected as this year?s charitable partners.
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?The American Gold Cup is one of the most prestigious equestrian competitions in the U.S., and I can think of no better place for this event than the stunning Old Salem Farm,? Astorino said. ?Westchester County is eager to welcome all the riders and fans. The county already has a long and proud history of equestrian sports, so it?s a perfect fit. Plus, beyond the event, we have top hotels, restaurants, arts and other attractions to keep visitors engaged all week long. It?s a perfect reason to say, ?Meet Me in Westchester.??
The American Gold Cup will be a signature event of the ?Meet Me in Westchester? tourism campaign, launched as part of the county?s Office of Tourism & Film. Westchester?s tourism industry is a major economic driver for the county, adding $1.7 billion to the economy and supporting 24,000 jobs.
The American Gold Cup is working with NBC Sports Network to produce a broadcast of the event on Sunday, Sept. 22 at 4:30 p.m. EST. The broadcast will be available to more than 80 million homes, highlighting Westchester and Old Salem Farm as premier equestrian sports destinations.
Astorino was joined for the announcement at Old Salem Farm by members of the American Gold Cup Team, including two-time Olympic Gold Medalist McLain Ward of nearby Brewster, N.Y. Also on hand were invited guests from the tourism, hospitality, equestrian, media and other local industries, who were treated to a behind-the-scenes tour of the newly renovated farm.
?Over the course of five days, the American Gold Cup will feature 600 horses and 300 riders from ?Europe, South America, Canada and across the United States,? said Frank Madden, Old Salem Farm head trainer and American Gold Cup organizer. ?This is truly a signature event for the equestrian community, and Old Salem Farm is proud to host all the great athletes, spectacular horses and supportive fans.?
The highlight of the event will be the $200,000 American Gold Cup Grand Prix. The Federation Equestre Internationale (FEI), which is the international governing body of equestrian sports, has designated the competition as a CSI 4*-W World Cup Qualifier, making the event of utmost importance for riders aspiring to compete at the 2014 World Cup Finals in Lyon, France.
?Last year it was an all-star cast,? said Michael Morrissey, president of Stadium Jumping and American Gold Cup organizer. ?We wanted everybody to come here and have a good experience and go away thinking this was the climax of the season. We feel we really accomplished that. This year, we are particularly excited to share the American Gold Cup in this incredible venue with television viewers across the country.?
In 2012, the North American Riders Group voted both Old Salem Farm and the American Gold Cup as among the ?Top 25? equestrian shows in North America. The farm?s recently completed $30 million renovation further helped to establish the property as a first-class show facility, highlighted by its pristine Grand Prix field.
Old Salem Farm is located only 45 minutes north of Manhattan, with three train stations only 10 minutes to the show with direct lines from Grand Central.
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?It?s one of the great competitions of our country,? said Ward, winner of the 2004 and 2008 Olympic Gold Medals for the U.S. Equestrian Team for Show Jumping.? ?A lot of people have been behind getting the Gold Cup to this venue because we believe what?s been done at Old Salem Farm in terms of the renovations and improvements is pretty special.?
Founded in 1970 and originally held in Cleveland, the American Gold Cup moved to Old Salem Farm in 2012, where it experienced record-breaking show entries and spectators in its inaugural year. Over the years the competition has enjoyed success in Tampa, Philadelphia and its former home for more than two decades, the Devon Horse Show grounds in Devon, Penn.
Whether on a national or local scale, the horse industry is known to have a diverse economic impact, involving agriculture, business, sport, gaming, entertainment and recreation.
In New York, the industry?s economic impact is roughly $2.4 billion, according to the American Horse Council Foundation. That doesn?t account for the off-site spending of spectators, though, which would result in an even higher figure. There are 202,000 horses statewide, over 70 percent of which are involved in showing and recreation. The industry directly supports 12,700 full-time jobs in New York, according to the 2005 report.
The American Gold Cup has selected the ASPCA and JustWorld International, which helps to provide basic education, nutrition, health, hygiene and vocational programs for children all over the globe, as this year?s charitable partners.
?The ASPCA is delighted to be selected as a charitable partner of the American Gold Cup and to be collaborating with a group of individuals that has been so incredibly proactive in supporting the ASPCA?s message of humane and responsible horsemanship,? said Valerie Angeli, senior director of equine and special projects for the ASPCA. ?We look forward to working with the ASPCA?s accomplished show jumping Equine Welfare Ambassadors at the event to educate, advocate and be a voice for horses.?
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Friday, March 1, 2013
New cancer 'vaccine' shows future promise in treating and preventing metastatic cancers
New cancer 'vaccine' shows future promise in treating and preventing metastatic cancers
Thursday, February 28, 2013Preclinical, laboratory studies suggest a novel immunotherapy could potentially work like a vaccine against metastatic cancers, according to scientists at Virginia Commonwealth University Massey Cancer Center. Results from a recent study show the therapy could treat metastatic cancers and be used in combination with current cancer therapies while helping to prevent the development of new metastatic tumors and train specialized immune system cells to guard against cancer relapse.
Recently published in the journal Cancer Research, the study detailed the effects of a molecule engineered by lead author Xiang-Yang Wang, Ph.D., on animal and cell models of melanoma, prostate and colon tumors. The molecule called Flagrp-170 consists of two distinct proteins, glucose-regulated protein 170 (Grp170), known as a "molecular chaperone," and a "danger signal" derived from flagellin, a protein commonly found in bacteria. The researchers used modified viruses, or adenoviruses, that can no longer replicate to transport Flagrp-170 directly to the tumor site to achieve localized vaccination. The novel therapy caused a profound immune response that significantly prolonged survival in animal models.
"Successfully promoting antitumor immunity will help eradicate tumor cells, control cancer progression and help prevent tumor relapse," says Wang, Harrison Scholar, member of the Cancer Molecular Genetics research program at VCU Massey Cancer Center and associate professor of Human and Molecular Genetics at VCU School of Medicine. "This immunotherapy has the potential to be used alone or in combination with conventional cancer treatments to develop and establish immune protection against cancer and its metastases."
Grp170 is currently being explored for its potential as a "cancer vaccine" because it has been shown to help the immune system recognize cancer antigens. Antigens are molecules from foreign objects such as bacteria, viruses or cancer that, when detected, provoke an immune response aimed at attacking them. However, because cancer cells can alter the microenvironment surrounding a tumor, they are able to suppress immune responses and continue replicating without being attacked by the body's natural defenses.
The chimeric chaperone Flagrp-170, created by strategically fusing a fragment of flagellin to Grp170, not only enhances antigen presentation, it also stimulates additional immune signals essential for functional activation of specialized immune cells, including dendritic cells, CD8+ T lymphocytes and natural killer (NK) cells. Dendritic cells act as messengers between the innate and adaptive immune systems. Once activated in response to a stimulus such as Flagrp-170, dendritic cells migrate to lymph nodes where they interact with other immune cells such as T lymphocytes to shape the body's immune response. CD8+ T lymphocytes and NK cells are known to respond to tumor formation and kill cancer cells by triggering apoptosis, a form of cell suicide.
"Overcoming cancer's ability to suppress the body's natural immune responses and restore or develop immunity for tumor eradication is the goal of cancer immunotherapy," says Wang. "More experiments are needed, but we are hoping Flagrp-170 may one day be used in formulating more effective therapeutic cancer vaccines."
Moving forward, Wang and his team are working to better understand the molecular mechanisms responsible for Flagrp-170's therapeutic effects. Additional studies are underway to more efficiently target and deliver Flagrp-170 to tumor sites in order to provoke a more robust and durable immune response.
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Virginia Commonwealth University: http://www.vcu.edu
Thanks to Virginia Commonwealth University for this article.
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Watson ponders careers in cooking, drug research as IBM makes it earn its keep
While mad game show skills are nice and all, IBM has started to nudge Watson toward the door to begin paying its own freight. After a recent foray into the financial industry, the publicity-loving supercomputer has now brought its number-crunching prowess to the pharmaceutical and pastry industries, according to the New York Times. If the latter sounds like a stretch for a hunk of silicon, it actually isn't: researchers trained Watson with food chemistry data, flavor popularity studies and 20,000 recipes -- all of which will culminate in a tasting of the bot's freshly devised "Spanish Crescent" recipe. Watson was also put to work at GlaxoSmithKlein, where it came up with 15 potential compounds as possible anti-malarial drugs after being fed all known literature and data on the disease. So far, Watson projects haven't made Big Blue much cash, but the company hopes that similar AI ventures might see its prodigal child finally pay back all those years of training.
Filed under: Science
Source: New York Times
Source: http://www.engadget.com/2013/02/28/ibm-watson-pastry-drug-research/
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